Negative and unpleasant; not likely to produce a good result.
Adverse change/circumstances/weather conditions
Lack of money will have an adverse effect on our research programme.(Oxford)
They have attracted strong adverse criticism.(Oxford)
So far the drug is thought not to have any adverse effects.(Cambridge)
adverse effect
attracted criticism
have adverse effects
Conflicting
Disadvantageous
Advantageous
Beneficial
Adversity
Adversely